CAR-T and TCR-T therapies that involve engineering a patients own immune cells with antigen-specific receptors have revolutionized blood cancer treatment. Nowscientists at Duke-NUS Medical School are exploring the possibility of turning the approach against COVID-19.
The idea of using CAR/TCR-T cell therapy has already been proposed for treating chronic viral infections such as HIV and hepatitis B. Based on previous research, Antonio Bertoletti from Duke-NUS emerging infectious diseases research program suggest these immunotherapies might also be useful in treating SARS-CoV-2, the virus causing the current pandemic.
We demonstrated that T cells can be redirected to target the coronavirus responsible for SARS. Our team has now begun exploring the potential of CAR/TCR T cell immunotherapy for controlling the COVID-19-causing virus, SARS-CoV-2, and protecting patients from its symptomatic effects, Bertoletti said in a statement.
Virtual Clinical Trials Online
This virtual event will bring together industry experts to discuss the increasing pace of pharmaceutical innovation, the need to maintain data quality and integrity as new technologies are implemented and understand regulatory challenges to ensure compliance.
These types of therapies involve modifying patients' own T cells with either a chimeric antigen receptor (CAR) or a T-cell receptor (TCR) that can recognize specific antigens associated with cancer,and then guiding the immune cells to eradicate the targets when infused back into the patients.
In a 2011 article published in the Journal of Virology, Bertoletti led a team that generated TCR-T cells that can go after SARS, another coronavirus that caused a deadly outbreak in China and other countries in late 2002 and early 2003.
The team showed that those TCR-redirected T cells displayed a functional profile similar to that of SARS-specific memory CD8 T cells from people who recovered from SARS-CoV infection. Based on the findings, the researchers suggested that TCR-T cells represent a promising prophylactic or therapeutic treatment for SARS.
RELATED:How 'duoCAR-T' cells could clear HIV and prevent resurgence of virus reservoirs
CAR-T cells have been explored in other viruses. A research team from the Albert Einstein College of Medicine and the University of Pittsburgh, for example,designed duoCAR-T cells that target three sites on the HIV envelope glycoprotein. In the lab, the cell therapy eliminated up to 99% of immune cells infected with different strains of HIV.
Despite thepromise of T-cell therapies, however, Bertoletti and colleague Anthony Tanoto Tan cautioned about potential safety concerns of using them to treat viral infections affecting vital organs. For one thing, CAR-T treatments havebeen linked to the dangerous side effect called cytokine release syndrome, in which overreactive immune cells launch an inflammatory response that can destroy organs, they said in a recent Journal of Experimental Medicine commentary. Similar cytokine storm effects have been reported in somesevere COVID-19 patients, leading to potentially life-threatening lung inflammations.
[T]he infusion ofT cells stably expressingpathogen-specific CAR/TCR poses therisk that these T cells might proliferate and wipe out all the infected cells that might be the majority of the infected organ, Bertoletti and Tanoto Tan wrote in their article.
To addressthat problem, Bertoletti and colleagues are using mRNA electroporation to engineer CAR/TCR T cells, which they say can limit their inflammatory capability and shorten the functional activity. That may offer a safer way to use engineered immune cells to treat viral diseases.
Several organizations are also working on cell therapies for COVID-19. AlloVir and Baylor College of Medicine have teamed up to develop an off-the-shelf therapy that entails exposing donor T cells to cytokines combined with viral fragments so the new cells can target the novel coronavirus. Celgene spinoff Celularity just started clinical trial of its cancer treatment CYNK-001 for COVID-19. The drugturns placental stem cells into one-size-fits-all natural killer cells.
See more here:
Scientists explore using CAR-T and other engineered immune cells to target COVID-19 - FierceBiotech
- Following Their Calling to Help Young Cancer Patients and Beyond - Stanford Children's Health - September 28th, 2024
- Greenberg Regenerative Medicine Celebrates Nearing 2 Years of Success with Pioneering VSEL Therapy - PR.com - September 28th, 2024
- Discovery clears hurdle in growing organs for transplants : Newsroom - UT Southwestern - September 26th, 2024
- Cell Therapy Market is Expected to Gain USD 60696.42 Million with a Growing CAGR of 19.20% by 2030 - openPR - September 25th, 2024
- Stem Cell Therapy Market To Reach USD 44 Billion By 2032 (Updated 2024) - Market.us Media - United States Market News - September 25th, 2024
- Doctors cured her sickle-cell disease. So why is she still in pain? - Nature.com - September 23rd, 2024
- The new frontier of luxury travel is a $44,000 course of stem cells and a longevity club stocked with IV stations - Fortune - September 23rd, 2024
- How stem cell and gene therapies are revolutionising healthcare - Express Healthcare - September 20th, 2024
- Exploring Regenerative Medicine and Its Impact on Modern Disease Management - Baltimore Post-Examiner - September 18th, 2024
- Stem Cell Therapy Market Dynamics: Size, Share, and Growth - openPR - September 16th, 2024
- Stem Cell Restore Review: Can It Boost Your Stem Cell Activity for Lasting Health? - Vashon-Maury Island Beachcomber - September 14th, 2024
- Stem Cell Therapy Market valued at USD 3.40 Billion by 2030 As Revealed In New Report - WhaTech - September 14th, 2024
- Stem Cell Manufacturing Market Projected to Witness Huge Growth by 2024-2031 As Revealed In New Report - WhaTech - September 14th, 2024
- Tesla BioHealing and Cell Biotechnology Partner to Advance Stem Cell Therapies - Vancity Buzz - September 12th, 2024
- Meso Numismatics Announces Cellgenics Sponsorship of Three Prominent Regenerative Medicine Events in Peru This September - StockTitan - September 10th, 2024
- Meso Numismatics Announces Cellgenics Sponsorship of Three Prominent Regenerative Medicine Events in Peru This September - Newswire - September 10th, 2024
- Breakthrough in blood stem cell development offers hope for leukemia and bone marrow failure - News-Medical.Net - September 8th, 2024
- Stem Cell Therapy Market Is Estimated To Reach $928.6 Million by 2031 | CAGR 16.2% - EIN News - September 8th, 2024
- USC researchers receive funding to develop next generation of intelligent biocomputers - EurekAlert - September 8th, 2024
- Risk Factors and Indications for Stem Cell Transplants in MDS - Targeted Oncology - September 6th, 2024
- Cell Therapy Market Size to Hit USD 28.98 Billion by 2032, - GlobeNewswire - September 6th, 2024
- Blood stem cells grown in the lab for the first time ever - Earth.com - September 6th, 2024
- Top 3 Grants in Regenerative Medicine: August 2024 - RegMedNet - September 6th, 2024
- New approach moves cell therapy closer to treating many disorders - Medical Xpress - September 4th, 2024
- Stem Cell Therapy Mexico: R3 Stem Cell Unveils Innovative and Affordable Non-Invasive Solutions - openPR - September 4th, 2024
- What Sets Immunotherapy Regenerative Medicine Apart in a Crowded Regenerative Market? - Flaunt Magazine - September 2nd, 2024
- Tiny Test Tubes Sort Stem Cells for Improved Therapy - The Scientist - August 31st, 2024
- Dr. Crandall: Stem Cell Treatment Heals the Heart - Newsmax - August 31st, 2024
- From stem cells to technology, the next Wisconsin RISE initiative focuses on improving health - University of Wisconsin-Madison - August 29th, 2024
- aHSCT Stem Cell Therapy for MS | National MS Society - National MS Society - August 29th, 2024
- Are Stem Cells the Secret to Anti-Aging? - The Edge - August 22nd, 2024
- A Comprehensive Review of the Role of Stem Cells in Neuroregeneration: Potential Therapies for Neurological Disorders - Cureus - August 22nd, 2024
- Scientists discover method to activate dormant stem cells in the brain - Medical Xpress - August 20th, 2024
- New way to extend 'shelf life' of blood stem cells can improve gene therapy - Medical Xpress - August 20th, 2024
- Where Are the Cell Therapies for Type 1 Diabetes? - Inside Precision Medicine - August 14th, 2024
- BioRestorative Therapies Reports Second Quarter 2024 Financial Results and Provides Business Update - GlobeNewswire - August 14th, 2024
- Stem Cell Therapy Market to expand to a market value of USD 3.40 Billion by 2030, with a CAGR of 13.4 percentage - openPR - August 14th, 2024
- Stem cell therapy unveiled: Discover the truth and boost donor rates - IOL - August 12th, 2024
- Stem Cell Therapy Market Set to Skyrocket to $48.89 Billion by 2033, Fueled by 13.2% CAGR - BioSpace - August 10th, 2024
- T.J. Watt Reveals He Received Stem Cell Treatment On Knee This Offseason - Steelers Depot - August 10th, 2024
- Anti-aging enthusiasts are getting $16,500 injections to make their knees young again - Business Insider Nederland - August 10th, 2024
- Regenerative Medicine Market Exclusive Insights on Size, Share and Profit - WhaTech - August 8th, 2024
- Fresh Study Reveals the Mesenchymal Stem Cells Market Trends, Strategy and Overview - WhaTech - August 6th, 2024
- Allogeneic Stem Cell Transplantation Market Exclusive Survey Report with Detailed Analysis to 2031 By Top R... - WhaTech - August 6th, 2024
- Salk awarded $3.6 million by the California Institute for Regenerative Medicine to advance research on brain aging - Salk Institute - August 2nd, 2024
- Professor awarded grant to study stem cell therapy for inflammatory bowel disorders - Mercer University - August 2nd, 2024
- Stem cell therapy advances: MSCs show potential in managing COVID-19 and influenza infections - News-Medical.Net - July 31st, 2024
- Scientists aboard international space station perform stem cell research and biomanufacturing in microgravity - BioProcess Insider - July 31st, 2024
- UCLA receives $2 million to develop regenerative medicine therapies for spinal cord injury - UCLA Newsroom - July 31st, 2024
- The Phoenix of stem cells: pluripotent cells in adult tissues and peripheral blood - Frontiers - July 31st, 2024
- Regenerative Medicine Market to Reach USD 194.9 Billion by 2032 - Market.us Media - United States Market News - July 31st, 2024
- Stem Cell Exosome Therapeutic Market Business Insights, Key Trend Analysis - Economica - July 31st, 2024
- One of the 7 people cured of HIV tells his story. Can his cure work for others? - Michigan Public - July 31st, 2024
- Novel stem cell treatment for osteoarthritis reduces pain by 58% - NewsBytes - July 30th, 2024
- Stem Cell Manufacturing Market Size To Reach $21.8 Billion By 2028 As Revealed In New Report - WhaTech - July 30th, 2024
- PRP, stem cell therapyhelp in curing infertility - The Times of India - July 30th, 2024
- Australian researchers develop a donor stem cell therapy for the successful treatment of osteoarthritis - News Hub - July 28th, 2024
- Seventh patient cured of HIV: why scientists are excited - Nature.com - July 28th, 2024
- Enggartiasto Lauds Stem Cell Therapy at RSCM - Jakartaglobe.id - July 28th, 2024
- Investigating the effect of alemtuzumab in allogeneic hematopoietic cell transplantation - Medical Xpress - July 28th, 2024
- Does This 'Stem Cell' Therapy Contain Any Actual Stem Cells? - Medscape - July 22nd, 2024
- Stem Cells and Malignant Mesothelioma - Mesothelioma.net Blog - July 18th, 2024
- Selma Blair on Getting Back on Track With MS Treatment: People Dont Get How Expensive It Is to Be Disabled - Hollywood Reporter - July 18th, 2024
- Common therapies contain different cell types, study finds - News-Medical.Net - July 18th, 2024
- Stem Cell Therapy with Saffron Extract Promotes Uterine Healing - Natural Science News - July 18th, 2024
- Half-matched stem cell transplant on 11-yr-old boy - The Times of India - July 12th, 2024
- Efficacy and Safety of Stem Cell Therapy for Orthopedic Conditions, Including Osteoarthritis and Bone Defects - Cureus - July 8th, 2024
- Stem Cell Therapy Market Poised to Reach USD 52.1 Billion by 2034 at a 12.1% of CAGR - PharmiWeb.com - July 8th, 2024
- "Living Fillings" Could be the Future Thanks to Stem Cells - NewBeauty Magazine - July 8th, 2024
- R3 Stem Cell Wins 2024 Global Regenerative Medicine Company of the Year for Third Time - EIN News - July 8th, 2024
- NUS Medicine team aims to start clinical trial of targeted therapy for deadly brain cancer in 2025 - The Straits Times - July 8th, 2024
- Sorting therapeutic stem cells by function improves healing after heart attack, lab study shows - Medical Xpress - July 4th, 2024
- July: cruk-grant | News and features - University of Bristol - July 4th, 2024
- Stem cell therapy shows promise for hirschsprung disease - Open Access Government - June 30th, 2024
- Stem Cells & Other Injectable Treatments: Solution or Scam? Episode 3 of 'The Bone Whisperers' Podcast - NYU Langone Health - June 28th, 2024
- Modulation of adipose-derived stem cell behavior by prostate pathology-associated plasma: insights from in vitro ... - Nature.com - June 28th, 2024
- Advancing regenerative medicine therapies UCI News - UCI News - June 26th, 2024
- Stem cell therapy could be breakthrough against type 1 diabetes - Medical Xpress - June 26th, 2024
- Paving the Way Toward Transplantation: NIH Awards Support Ophthalmology Retinal Research - University of Colorado Anschutz Medical Campus - June 26th, 2024
- Stem Cell Therapy Could Be Breakthrough Against Type 1 Diabetes - The Caledonian-Record - June 26th, 2024
Recent Comments