NIH researchers develop gene therapy for rare ciliopathy – National Institutes of Health (.gov)
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News Release Thursday, September 8, 2022 Gene augmentation rescues cilia defects in light-sensing cells derived from patients with blinding disease. Researchers from the National Eye Institute (NEI) have developed a gene therapy that rescues cilia defects in retinal cells affected by a type of Leber congenital amaurosis (LCA), a disease that causes blindness in early childhood. Using patient-derived retina organoids (also known as retinas-in-a-dish), the researchers discovered that a type of LCA caused by mutations in the NPHP5 (also called IQCB1) gene leads to severe defects in the primary cilium, a structure found in nearly all cells of the body. The findings not only shed light on the function of NPHP5 protein in the primary cilium, but also led to a potential treatment for this blinding condition. NEI is part of the National Institutes of Health

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Aflac and Be The Match partner to help diversify the National Blood Stem Cell Donor Registry and improve health equity – PR Newswire
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NBA player Marcus Smart joins partnership to advocate for patients battling blood cancers and blood diseases COLUMBUS, Ga. and MINNEAPOLIS, Sept. 8, 2022 /PRNewswire/ -- Highlighting its 27-year commitment to children and families facing childhood cancer and sickle cell disease (SCD), Aflac, the number one provider of supplemental health insurance in the U.S.1 and Be The Match, operated by the National Marrow Donor Program, which has helped facilitate more than 111,000 blood stem cell transplants worldwide, today announced a partnership to continue diversifying the national blood stem cell donor registry. The agreement is part of Aflac's overall campaign commemorating National Childhood Cancer Awareness Month and National Sickle Cell Awareness Month, both of which occur in September. Since 1995, Aflac has contributed more than $160 million to the Aflac Cancer and Blood Disorders Center at Children's Healthcare of Atlanta, the largest sickle cell care provider in the United States

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New stem cell therapy provides long-term brain protection against ALS – Study Finds
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LOS ANGELES Cedars-Sinai researchers say a new stem cell therapy procedure allows them to protect patients with ALS, or Lou Gehrigs disease, and helps block muscle deterioration which normally occurs as a result of the fatal neurological disorder. The Cedars-Sinai team successfully engineered and embedded protective proteins through the blood-brain barrier of patients with amyotrophic lateral sclerosis (ALS). The procedure increases hope that similar one-time treatments will greatly slow the diseases degenerative effects, including limb paralysis and the loss of ones ability to move, speak, or breathe. Researchers did not encounter any negative side-effects, while patients avoided leg paralysis following the transplant and replication of protein-producing stem cells from patients central nervous systems. This breakthrough investigational therapy promotes the survival of motor neurons which typically degenerate in the spinal cord of patients with ALS

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Largest Gift in UCSD History to Fund Stem Cell Research on Space Station – Times of San Diego
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Scanning electron micrograph of cultured human neuron from induced pluripotent stem cell. Photo via Mark Ellisman and Thomas Deerinck, National Center for Microscopy and Imaging Research, UC San Diego UC San Diego will use the largest single gift in its history to fund an institute tasked with expanding stem cell research and regenerative medicine, it was announced Tuesday. The $150 million gift from businessman and philanthropist T. Denny Sanford follows up on his $100 million gift in 2013, which established UCSD as a leader in developing and delivering the therapeutic promise of human stem cells

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University of Colorado’s ocular stem cell and regenerative research program recognized – Ophthalmology Times
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The University of Colorado Department of Ophthalmologys ocular stem cell and regeneration research program, CellSight, was awarded two prizes in the National Eye Institutes 3D Retinal Organoid Challenge (NEI 3D ROC). The NEI, part of the National Institutes of Health, launched the three-phase challenge in 2017 to stimulate research using retina organoids. These organoids are similar to human retinas but aregrown in a lab from stem cells, enabling researchers to study eye diseases and treatments noninvasively. CellSightDirectorValeria Canto-Soler, PhD, Doni Solich Family Chair in Ocular Stem Cell Research, led the team that won the NEI 3D ROCs disease modeling category, earning $500,000.Natalia Vergara, PhD, director ofCellSightsOcular Development and Translational Technologies Laboratory, led the research group that won the drug-screening category, earning $250,000. According to a University of Colorado news release, Canto-Solers research group created a three-dimensional retinal model that recreates pathological features of age-related macular degeneration, with the ultimate goal of discovering new treatments for this blinding disease

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Global Recombinant Cell Culture Supplements Market Report 2022: Increasing Need for Immunotherapies and Stem Cell and Regenerative Medicines Presents…
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Company Logo Global Recombinant Cell Culture Supplements Market Global Recombinant Cell Culture Supplements Market Dublin, Sept. 05, 2022 (GLOBE NEWSWIRE) -- The "Global Recombinant Cell Culture Supplements Market: Focus on Pricing Analysis, Product, Application, Expression System, and Region - Analysis and Forecast, 2022-2032" report has been added to ResearchAndMarkets.com's offering. The global recombinant cell culture supplements market was estimated at $308.6 million in 2021 and is expected to reach $1,188.6 million by 2032, growing at a CAGR value of 12.24% during the forecast period 2022-2032. The growth in the global recombinant cell culture supplements market is expected to be driven by the rising demand for cell culture supplements, increasing investment in life sciences research and development, as well as growing advantages of recombinant supplements over traditional animal-derived supplements. Market Lifecycle Stage The global recombinant cell culture market is increasing at a rapid pace

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ADOCIA Announces First Cell Therapy Preclinical Proof of Concept of AdoShell Islets for the Treatment of Type 1 Diabetes – Business Wire
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LYON, France--(BUSINESS WIRE)--Regulatory News: Adocia (Euronext Paris: FR0011184241 ADOC), a clinical-stage biopharmaceutical company focused on the research and development of innovative therapeutic solutions for the treatment of diabetes and other metabolic diseases, announces the establishment of a first proof of concept for its AdoShell Islets implant by achieving glycemic control without insulin injections in immunocompetent diabetic rats during the 132-day study. "Adocias results are remarkable, having successfully performed the first islet transplantation without the use of immunosuppressants in immunocompetent animals. We are delighted to be actively involved in these unprecedent results, said Dr. Karim Bouzakri, Director of CEED (European Center for the Study of Diabetes). AdoShell Islets is an immuno-protective synthetic biomaterial containing islets of Langerhans.

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Hill International to Provide Project Management and Supervision Consultancy Services for the International Stem Cell and Regenerative Medicine…
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News and research before you hear about it on CNBC and others. Claim your 1-week free trial to StreetInsider Premium here. PHILADELPHIA and CAIRO, Egypt, Aug. 30, 2022 (GLOBE NEWSWIRE) -- Hill International(NYSE: HIL), delivering the infrastructure of change, announced today it was selected by Egypts Ministry of Defense to provide project management and supervision consultancy services for the International Stem Cell and Regenerative Medicine Research and Therapeutic Center project. The project represents the latest effort of the Egyptian Armed forces to enrich the countrys healthcare sector

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