-Safety switches can be applied to CAR T, stem cell, and TCR Therapies - -Cells are created using a gene knockout, maintaining stability of the cells, avoiding additional genetic material and immunogenicity - -Manufacturing process enables 100% population of cells with a safety switch - LONDON--(BUSINESS WIRE)-- Auxolytic, a company developing novel nutrient-based control switches to address safety issues associated with cellular therapies, today announced the publication of foundational research on its approach in Nature Biotechnology. In the paper, entitled "Metabolic engineering generates a transgene-free safety switch for cell therapy, Auxolytic, in collaboration with researchers at Stanford University School of Medicine, demonstrates that it has developed a novel safety off switch for various types of cell therapies, potentially enabling a physician to mitigate serious side-effects when they are observed. The switch works by knocking out a specific gene in the cell, creating a dependency on a particular nutrient for its survival
Recent Comments