Bone Marrow Improves Healing With ACL Grafts – MedPage Today

Patients undergoing anterior cruciate ligament (ACL) reconstruction with allografts appeared to heal more quickly when injections of bone marrow aspirate were included, according to a randomized trial. Magnetic resonance imaging (MRI) scans at 3 months showed significantly higher signal intensity in the inferior third of the allograft for patients who received the stem cell-rich injections, relative to patients receiving sham injections with the allograft, reported Ophelie Lavoie-Gagn, a medical student at the University of California, San Diego.

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Transcriptome and regulatory maps of decidua-derived stromal cells inform gene discovery in preterm birth – Science Advances

While a genetic component of preterm birth (PTB) has long been recognized and recently mapped by genome-wide association studies (GWASs), the molecular determinants underlying PTB remain elusive. This stems in part from an incomplete availability of functional genomic annotations in human cell types relevant to pregnancy and PTB. We generated transcriptome (RNA-seq), epigenome (ChIP-seq of H3K27ac, H3K4me1, and H3K4me3 histone modifications), open chromatin (ATAC-seq), and chromatin interaction (promoter capture Hi-C) annotations of cultured primary decidua-derived mesenchymal stromal/stem cells and in vitro differentiated decidual stromal cells and developed a computational framework to integrate these functional annotations with results from a GWAS of gestational duration in 56,384 women

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