Genome Research Papers on Cancer Chromatin, Splicing in the Thymus, Circular RNAs in Cancer – GenomeWeb
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A team from the US, France, and Australia investigates chromatin sites carrying histone modification marks linked to both transcriptional activation and repression "bivalent chromatin" sites with potential roles in development and cancer. "Most gene promoters DNA-hypermethylated in adult human cancer are bivalently marked in [embryonic stem cells]," the researchers write. Based on available epigenetic data and their own experiments in pluripotent human and mouse embryonic stem cells, they suggest that promoters with both the H3K4me3 transcriptional activation and the repressed chromatin-related H3K27me3 marks may be protected against de novo DNA methylation

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ViaCyte to Participate in International Pancreas & Islet Transplantation Association Virtual Congress – KY3
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Published: Oct. 19, 2021 at 7:00 AM CDT SAN DIEGO, Oct. 19, 2021 /PRNewswire/ -- Evert Kroon, Ph.D., Vice President of Translation Research at ViaCyte, Inc., an innovator in cellular therapy and regenerative medicine, will participate in the International Pancreas & Islet Transplantation Association (IPITA) Virtual Congress' session, "Islet Organoids From Pluripotent and Adult Stem Cells" on Friday, October 22, 2021 from 8:05-9:05 a.m.

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TCRR Stock: Why It Increased Today – Pulse 2.0
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The stock price of TCR2 Therapeutics a clinical-stage cell therapy company with a pipeline of novel T cell therapies for patients suffering from solid tumors increased by over 1% pre-market today. Investors responded positively to TCR2 Therapeuticsunveiling new programs and provided highlights from its emerging TRuC pipeline programs during its first virtual R&D Day. Pipeline Updates Gavo-cel: TCR2 announced the completion of the 3-patient cohort at the new dose level 3.5A (3108/m2 following lymphodepletion) using a split dosing approach.

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Better Days Ahead for Patients With AML – Curetoday.com
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As an almost 30-year veteran of the Secret Service, Jim Helminski took pride in maintaining his physical health both for his own sake and to be better fit to protect others. His demanding career placed the safety of Presidents Bill Clinton and George W. Bush and then-Vice President Joe Biden in his hands

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Research reveals the mechanisms of cardiac sex disparities at an early stage – News-Medical.net
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Males and females differ in prevalence, treatment responses, and survival rates for a variety of diseases. For cardiac disease, women almost uniformly fare far worse than men. There are likely many reasons for this, and scientists at the University of North Carolina at Chapel Hill and Princeton University seemed to have found one deep inside cells before we're even born

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Stem cell controversy – Wikipedia
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Ethical controversy over the use of embryonic stem cells The stem cell controversy is the consideration of the ethics of research involving the development and use of human embryos. Most commonly, this controversy focuses on embryonic stem cells. Not all stem cell research involves human embryos

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Regenerative therapy linked to QOL benefit for patients with SUI – Urology Times
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Stress urinary incontinence is a consistent health issue in female patients that is typically treated with surgical interventions. Clinicians have investigated less invasive treatments for this debilitating condition, but the question is whether they are safe and produce positive results. In a recent study presented at the 2021 American Urological Association Annual Meeting, Melissa R.

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