Banking on iPSCs | The Scientist

WIKIMEDIA, GOLDMUND100About four years ago, Jay Tischfield, the director of RUCDR Infinite Biologics, a long-standing biorepository at Rutgers University, found himself sitting on a gold mine. RUCDR had recently gotten into the business of banking induced pluripotent stem cell (iPSC) lines as part of an initiative through the National Institute of Mental Health (NIMH). This was still early days in iPSC derivation, a few years after the pioneers of the field had figured out how to turn skin cells into pluripotent cells.

But not long into this new endeavor, something important happened in the field, Tischfield recalled. Researchers reported for the first time that they could induce pluripotency from blood cells. It just so happened that RUCDR was in possession of a massive collection of blood cell lines, each with a heap of information on the donor. There we were, standing on what is perhaps one of the worlds, if not the worlds, largest collection of genetically defined . . . lymphocytes from literally almost a half a million subjects, he said.

All of these non-transformed small lymphocytes had been cryopreserved as back-ups for transformed cell lines. And it turned out these were fantastic for making iPSCs, said Tischfield. We could make iPSCs with about a 95 ...

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Banking on iPSCs | The Scientist