Money on the Move: January 27 February 2 – BioSpace

The groundhog saw his shadow, meaning six more weeks of winter. But there's no freezing of funds in the biopharma world. Here's a recap of where life sciencescash has been flowing the past week.

Sana Biotechnology

Initially filing for a$150 million IPO, Seattle-based Sanaamendedto amassivegoal of$323 million,offering 15 million shares at $20 to $23 per share.Although the company is still at a preclinical stage,this IPOwould value the company at a price of nearly $4.5 billion.Prime focuses of startup company Sana Biotechnology include the development ofin vivoandex vivocell engineering platformslicensedfrom Harvard University to discover novel treatments across several therapeutic areas that currently have unmet treatment needs. Therapeutic areas of particular interest to the company include oncology, diabetes, central nervous system (CNS) disorders, cardiovascular diseases and genetic disorders. IND applications are anticipated in 2022 and 2023. Last summer Sana raised$700 million ininitial financing.

Design Therapeutics

Launched last Marchwith $45 million to create a new class of disease-modifying therapies,Design Therapeutics secured another$125 million this week in a Series B.In the short time since our launch, Design Therapeutics has made significant progress in the advancement of our novelGeneTACplatform focused on addressing the underlying causes of serious degenerative diseases, said Joo Siffert, M.D., president and chief executive officer of Design Therapeutics. This capital raise provides important resources to efficiently advance our pipeline, including our lead programs in Friedreich ataxia and myotonic dystrophy type-1. Proceeds will be used to advance theGeneTACplatform to develop a pipeline ofGeneTACmolecules with an initial focus on nucleotide repeat expansion disorders, including Friedreich ataxia. Design hopes to be in the clinic by the first half of 2022.

Nuvalent

Launching with a$50 million Series A,Nuvalentistackling the most common type of lung cancer NSCLC. The funds raised will fuelNuvalentsR&D efforts towardbuildinga portfolioof innovative small molecule kinase inhibitors for programs in NSCLC. Therapeuticagents include a potential best-in-class ROS1-selective inhibitor, NUV-520, and an ALK-selective inhibitor, NUV-655.The companys first lead program involving NUV-520 will examine the molecules efficacy in treating advanced NSCLC, particularly cases that have developed resistance to treatment, driven by a ROS1 fusion. The first Phase I/II trial investigating the potential therapy in NSCLC is expected for the second half of this year. Another program targeting NSCLC tumors driven by an ALK fusion is anticipated in 2022.

Ukko

On a mission to eliminate food allergies and sensitivities, a massive needs market, Ukko scooped up$40 million in a Series B round.Using an AI-driven protein engineering platform, the company isdevelopinga promising investigational therapy for peanut allergies.Ukko is also working on an improved gluten for people with Celiac disease and other gluten sensitivities to be able to enjoy.Data on both of these programs suggest these do not trigger allergic responses in the immune systems of patients. The new fundingwilltake Ukko to clinical trial with its peanut allergy therapeutic.Pharma-giantBayer was aleadinvestor in the round.

Cellino

Artificial intelligence is impacting the future of every industry, and the life sciences industry is no different. Using image-guided machine learning AI, Cambridge-based Cellinois guiding automated cell reprogramming, expansion and differentiation. Launchedin 2017, the company just completed a$16 million seed roundtoenable its induced pluripotent stem cell (iPSC) engineering platform, powered by artificial intelligence.Autologous iPSCs cells taken from a patient, engineered for therapeutic benefit and returned to the patient have been in clinical testing since 2014, but none have reached regulatory approval.Cellinos platform will allow it to precisely steer iPSCs to a target tissue state.

Endogena

Discovering and developing regenerative medicines from within,Endogenabrought in$8 millionin a Series A financing round last week.Focused on novel treatments for neurodegenerative diseases, the funds will help its lead program aimed at retinitis pigmentosa to establish clinical proof-of-concept.EndogenasAI-driven platform is a combination of stem cell research and small molecule drug discovery. The company also hopes to advance its age-related macular degeneration program to an IND.

AffyXell

Established last January to develop novel mesenchymal stem cell therapies,AffyXellclosed aSeries A for $7.3 millionto develop its pipeline of next-gen cell and gene therapies.The biotech combines Avacta TherapeuticssAffimerplatform withDaewoongPharmaceuticals MSC platform to genetically modify stem cells tosecreteAffimerproteins that enhance the therapeutic effectsof the MSC. Funds from the series will be used for further development oftherapies that will suppress immune response and restore balance for inflammatory and autoimmune diseases.

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Money on the Move: January 27 February 2 - BioSpace