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Qing-Shu Menget al. World J Stem Cells. 2020.
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Mesenchymal stem/stromal cells (MSCs) have various properties that make them promising candidates for stem cell-based therapies in clinical settings. These include self-renewal, multilineage differentiation, and immunoregulation. However, recent studies have confirmed that aging is a vital factor that limits their function and therapeutic properties as standardized clinical products. Understanding the features of senescence and exploration of cell rejuvenation methods are necessary to develop effective strategies that can overcome the shortage and instability of MSCs. This review will summarize the current knowledge on characteristics and functional changes of aged MSCs. Additionally, it will highlight cell rejuvenation strategies such as molecular regulation, non-coding RNA modifications, and microenvironment controls that may enhance the therapeutic potential of MSCs in clinical settings.
Keywords: Features; Function; Mesenchymal stem cells; Rejuvenation strategy; Senescence.
The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
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Conflict-of-interest statement: The authors declare that they have no conflicts of interest related to this work.
Figure 1
Effects of senescent mesenchymal stem
Figure 1
Effects of senescent mesenchymal stem cells on target cells. A: Effects of aged
Effects of senescent mesenchymal stem cells on target cells. A: Effects of aged mesenchymal stem cells (MSCs) on immune cells; B: Effects of aged MSCs on other target cells, including hematopoietic stem and progenitor cells, neural stem cells, and multiple myeloma cells. DCs: Dendritic cells; HSPCs: Hematopoietic stem and progenitor cells; NSCs: Neural stem cells; OPCs: Oligodendrocyte progenitor cells; MM cells: Multiple myeloma cells; MSCs: Mesenchymal stem cells; PHA: Phytohemagglutinin; GM-CFUs: Granulocyte macrophage-clone formation units; MBP: Myelin basic protein; CNP: 2',3'-cyclic-nucleotide 3'-phosphodiesterase.
Weng Z, Wang Y, Ouchi T, Liu H, Qiao X, Wu C, Zhao Z, Li L, Li B. Weng Z, et al. Stem Cells Transl Med. 2022 Apr 29;11(4):356-371. doi: 10.1093/stcltm/szac004. Stem Cells Transl Med. 2022. PMID: 35485439 Free PMC article. Review.
Liu J, Ding Y, Liu Z, Liang X. Liu J, et al. Front Cell Dev Biol. 2020 May 5;8:258. doi: 10.3389/fcell.2020.00258. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 32478063 Free PMC article. Review.
Zhou X, Hong Y, Zhang H, Li X. Zhou X, et al. Front Cell Dev Biol. 2020 Jun 3;8:364. doi: 10.3389/fcell.2020.00364. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 32582691 Free PMC article. Review.
Jin HJ, Kwon JH, Kim M, Bae YK, Choi SJ, Oh W, Yang YS, Jeon HB. Jin HJ, et al. Stem Cells Transl Med. 2016 Apr;5(4):427-39. doi: 10.5966/sctm.2015-0109. Epub 2016 Mar 3. Stem Cells Transl Med. 2016. PMID: 26941359 Free PMC article.
Sekelova T, Danisovic L, Cehakova M. Sekelova T, et al. Cell Transplant. 2023 Jan-Dec;32:9636897231200065. doi: 10.1177/09636897231200065. Cell Transplant. 2023. PMID: 37766590 Free PMC article. Review.
Zheng Q, Zhang S, Guo WZ, Li XK. Zheng Q, et al. Front Immunol. 2021 Apr 6;12:659621. doi: 10.3389/fimmu.2021.659621. eCollection 2021. Front Immunol. 2021. PMID: 33889158 Free PMC article. Review.
Wei F, Tuong ZK, Omer M, Ngo C, Asiatico J, Kinzel M, Pugazhendhi AS, Khaled AR, Ghosh R, Coathup M. Wei F, et al. Bone Res. 2023 Jun 29;11(1):34. doi: 10.1038/s41413-023-00273-w. Bone Res. 2023. PMID: 37385982 Free PMC article.
Smith N, Shirazi S, Cakouros D, Gronthos S. Smith N, et al. Int J Mol Sci. 2023 Mar 30;24(7):6499. doi: 10.3390/ijms24076499. Int J Mol Sci. 2023. PMID: 37047469 Free PMC article. Review.
Paganelli A, Trubiani O, Diomede F, Pisciotta A, Paganelli R. Paganelli A, et al. Front Oral Health. 2021 Mar 31;2:635055. doi: 10.3389/froh.2021.635055. eCollection 2021. Front Oral Health. 2021. PMID: 35047993 Free PMC article.
Paganelli A, Diomede F, Marconi GD, Pizzicannella J, Rajan TS, Trubiani O, Paganelli R. Paganelli A, et al. Biomedicines. 2023 May 24;11(6):1519. doi: 10.3390/biomedicines11061519. Biomedicines. 2023. PMID: 37371614 Free PMC article.
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