Recent advances have come from the establishment of stem cell lines representative of early human embryo lineages. 1, 2 Human pluripotent stem cells (PSCs) possess a high degree of cellular plasticity, which has enabled strategies to guide PSCs into multiple embryonic and extra-embryonic cell types. 3, 4, 5 Remarkable progress has been made in modeling the human and non-human primate embryo by ...

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Early human development and stem cell-based human embryo models

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